||Method for Combining and Comparing Short-Term Genotoxicity Test Data: Preface. A Report from ICPEMC Committee 1.
Brusick, D. J. ;
Ashby, J. ;
de Serres, F. J. ;
Lohman, P. H. M. ;
Matsushima, T. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Leiden Rijksuniversiteit (Netherlands). ;Lawrence Livermore National Lab., CA. ;Hazleton Labs. America, Inc., Vienna, VA.;Department of Energy, Washington, DC.
Mutagenicity tests ;
Chromosome aberrations ;
Neoplastic cell transformation ;
DNA repair ;
Dose-response relationships ;
Statistical analysis ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Short-term testing methods, encompassing a wide variety of species and genetic mechanisms, have been developed to detect genetic effects produced by chemicals. The use of multiplicity of tests has created a difficult and controversial challenge in the interpretation of mixed test results. The driving principle of this report and the International Commission for Protection against Environmental Mutagens and Carcinogens (ICPEMC) Committee 1 was to combine the major parameters of testing (dose, metabolic activation, sign of response, and the replication of test data) into a single score which could be pooled by entry, by test (e.g., Salmonella reverse mutation), by test class (e.g., bacterial mutation), and by family (in vitro or in vivo), into a composite score for a chemical. The system is designed: (i) to cope with redundant data, disagreement, and sporadically filled matrices; (ii) to supply statistical properties by chemical and by test; and (iii) to have features of self-learning to improve predictive performance and internal consistency for any one of several types of genetic hazard.
||Pub. in Mutation Research, v266 n1 p7-25 Mar 92. See also PB89-109680. Prepared in cooperation with Leiden Rijksuniversiteit (Netherlands), Lawrence Livermore National Lab., CA., and Hazleton Labs. America, Inc., Vienna, VA. Sponsored by Department of Energy, Washington, DC.
|NTIS Title Notes
||Reprint: Method for Combining and Comparing Short-Term Genotoxicity Test Data: Preface. A Report from ICPEMC Committee 1.
||PC A04/MF A01