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OLS Field Name OLS Field Data
Main Title Method for Combining and Comparing Short-Term Genotoxicity Test Data: Preface. A Report from ICPEMC Committee 1.
Author Brusick, D. J. ; Ashby, J. ; de Serres, F. J. ; Lohman, P. H. M. ; Matsushima, T. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Leiden Rijksuniversiteit (Netherlands). ;Lawrence Livermore National Lab., CA. ;Hazleton Labs. America, Inc., Vienna, VA.;Department of Energy, Washington, DC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-93/399;
Stock Number PB93-236362
Additional Subjects Mutagenicity tests ; Mutagens ; Comparison ; Chromosome aberrations ; Neoplastic cell transformation ; Drosophila ; DNA repair ; Dose-response relationships ; Statistical analysis ; Reprints ;
Holdings
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NTIS  PB93-236362 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 11/22/1993
Collation 63p
Abstract Short-term testing methods, encompassing a wide variety of species and genetic mechanisms, have been developed to detect genetic effects produced by chemicals. The use of multiplicity of tests has created a difficult and controversial challenge in the interpretation of mixed test results. The driving principle of this report and the International Commission for Protection against Environmental Mutagens and Carcinogens (ICPEMC) Committee 1 was to combine the major parameters of testing (dose, metabolic activation, sign of response, and the replication of test data) into a single score which could be pooled by entry, by test (e.g., Salmonella reverse mutation), by test class (e.g., bacterial mutation), and by family (in vitro or in vivo), into a composite score for a chemical. The system is designed: (i) to cope with redundant data, disagreement, and sporadically filled matrices; (ii) to supply statistical properties by chemical and by test; and (iii) to have features of self-learning to improve predictive performance and internal consistency for any one of several types of genetic hazard.
Supplementary Notes Pub. in Mutation Research, v266 n1 p7-25 Mar 92. See also PB89-109680. Prepared in cooperation with Leiden Rijksuniversiteit (Netherlands), Lawrence Livermore National Lab., CA., and Hazleton Labs. America, Inc., Vienna, VA. Sponsored by Department of Energy, Washington, DC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Method for Combining and Comparing Short-Term Genotoxicity Test Data: Preface. A Report from ICPEMC Committee 1.
Category Codes 57Y; 57F
NTIS Prices PC A04/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 330925753
Origin NTIS
Type CAT