||Interdisciplinary Approach to Assessing the Health Risk of Air Toxic Chemicals: An Overview.
Grose, E. C. ;
Selgrade, M. J. K. ;
Busnell, P. J. ;
Simmons, J. E. ;
Allen, J. ;
||Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Air pollution effects(Humans) ;
Risk assessment ;
Health hazards ;
Mutagenicity tests ;
Immune system ;
Nervous system ;
Environmental exposure pathways ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||To assist the regulatory branch of the Environmental Protection Agency in addressing the risk assessment of air toxics, the Health Effects Research Laboratory initiated a comprehensive inhalation toxicology program to provide key health effects data missing from the current data base. A priority ranking of chemicals based on the potential for substantial human exposure and the need for health effects data was developed to identify candidate chemicals for toxicological research. The major goal of the program is to evaluate the concentration-response from acute, intermittent and subchronic inhalation exposures to developmental, genetic, hepatic, immunologic, neurologic, pulmonary and reproductive toxicity. Although the main emphasis is on inhalation as the primary route of exposure, some of the laboratories will compare inhalation to other routes, such as oral, to better understand the influence of route of exposure and hence the potential applicability of existing health data. Acute and intermittent exposures will be done for all compounds. Upon evaluation of the acute results, a decision will be made as to whether subchronic studies are needed. Endpoints that show unusual sensitivity may be investigated in greater detail. The total length of exposure will vary from 1 to 21 days. The daily length of exposure will range from 1 to 8 hr. If adverse effects are observed at ambient levels, the time to recovery after exposure will be investigated. (Copyright (c) 1990 Princeton Scientific Publishing Co., Inc.)
||Pub. in Toxicology and Industrial Health, v6 n5 p157-169 Sep 90. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Interdisciplinary Approach to Assessing the Health Risk of Air Toxic Chemicals: An Overview.
||PC A03/MF A01