| Main Title |
Synaptonemal Complex Analysis in Genetic Toxicology. |
| Author |
Backer, L. C. ;
Moses, M. J. ;
Allen, J. W. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. |
| Publisher |
1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/D-89/155; |
| Stock Number |
PB90-119249 |
| Additional Subjects |
Genetics ;
Mice ;
Genetic radiation effects ;
Cells(Biology) ;
Meiosis ;
Synaptonemal complex ;
Sex chromosome abnormalities ;
Dose-response relationships ;
Karyotyping
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-119249 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
Synaptonemal complex analysis provides a unique means of visualizing the behavior of meiotic chromosomes. The technique has been applied to the study of normal karyotypes and mutant stocks of mice. Recent work demonstrating the usefulness of SC analysis for the detection of chromosome damage suggests its potential application in a variety of mechanistic and applied studies. Studies investigated cell-stage specific damage included by radiation and expressed as SC and/or metaphase chromosome aberrations. Radiation was found to exhibit a similar stage-specific clastogenic activity for SCs as it does for meiotic metaphase chromosomes. The nature of the chromosome damage detected depend upon the cell stage exposed and on the endpoint harvested for analysis. |
| Supplementary Notes |
Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC., and Duke Univ. Medical Center, Durham, NC. |
| Category Codes |
57F; 57E |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
935223464 |
| Origin |
NTIS |
| Type |
CAT |
