OLS : Record

RECORD NUMBER: 48 OF 726

Main Title Acute Skin Absorption Ld50 Testing on Rabbits.
CORP Author Du Pont de Nemours (E.I.) and Co., Wilmington, DE.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 86-870001092
Stock Number OTS0514995
Subjects Toxicology; Health effects; Hexanedinitrile (111-69-3); Acute Toxicity; Mammals; Rabbits; Dermal; Toxic substances; Laboratory animals; CAS No 111-69-3
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS OTS0514995 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 3p
Abstract Acute dermal toxicity was evaluated in groups of 6 male New Zealand White rabbits receiving single occluded applications of hexanedinitrile at dose levels of 1000, 1250, 1350, 1500, 2000, and 4000 mg/kg of body weight. The test article was held in contact with the intact skin for a period of 24 hours. Mortality was observed within 14 days of treatment in 3-4 animals at dose levels 1350 to 4000 mg/kg; the LD50 was calculated to be 2134 mg/kg of body weight. Clinical observations included gasping, diarrhea and lethargy. Intermittent weight loss was noted at all levels. Gross necropsy was not reported.
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PUB Date Free Form 2000
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A01/MF A01
Document Type NT
Control Number 028801980
Cataloging Source NTIS/MT
Origin NTIS
Type CAT