OLS : Record

RECORD NUMBER: 31 OF 855

Main Title Analyses of Cytogenetic Damage in Rodents Following Exposure to Simulated Groundwater Contaminated with Pesticides and a Fertilizer.
Author Kligerman, A. D.; Chapin, R. E.; Erexson, G. L.; Germolec, D. R.; Kwanyuen., P.;
CORP Author National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
Publisher c1993
Year Published 1993
Report Number EPA-68-02-4456; EPA/600/J-94/204;
Stock Number PB94-163839
Subjects Chromosome aberrations; Pesticides; Groundwater; Water pollution effects(Animals); Herbicides; Fertilizers; Toxicity; Ammonium nitrates; Sister chromatid exchange; Rats; Mice; Mutagens; California; Iowa; Reprint; Genotoxicity
Holdings
Library   Call Number Additional Info Location Date Modified
NTIS PB94-163839 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/01/1994
Collation 12p
Abstract Male Fischer 344 rats and female B6C3F1 mice were each exposed through their drinking water to a mixture of pesticides and ammonium nitrate that simulated contaminated groundwater in California (California Chemical Mixture (CCM)). Exposures were for 71 or 91 days, respectively. In addition, B6C3F1 female mice were exposed for 91 days to another pesticide and ammonium nitrate mixture (Iowa Chemical Mixture (ICM)) through their drinking water. The spleens were removed from the animals, and the splenocytes were cultured for analyses of sister-chromatid exchange (SCE), chromosome aberrations (CA), and micronucleic (MN) in cytochalasin B-induced binucleate cells. A concentration-related increase in SCEs was found in the splenocytes of the rat at the 1 x, 10 x and 100 x levels of the CCM and at the 100 x concentration of the CCM in the mouse. (Copyright (c) 1993 Elsevier Science Publishers B.V.)
Supplementary Notes Pub. in Mutation Research v300 n2 p125-134 Jul 93. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
Highlights Notes %AUT:R. S. H. /Yang
NTIS Title Notes Journal article.
Title Annotations Reprint: Analyses of Cytogenetic Damage in Rodents Following Exposure to Simulated Groundwater Contaminated with Pesticides and a Fertilizer.
Category Codes 57Y; 57F; 68D; 98A; 68E
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Control Number 416823469
Cataloging Source NTIS/MT
Origin NTIS
Type CAT