OLS : Record


Main Title Dose-Effects Functions for Carboxyhemoglobin and Behavior.
Author Benignus, V. A.; Muller, K. E.; Smith, M. V.; Pieper, K. S.; Prah, J. D.;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 10 Apr 89
Year Published 1989
Report Number EPA-68-02-3800; 3E162787A878; CA;
Stock Number AD-A221 043/3
Subjects Behavior; Carboxylic acids; Documents; Functions; Graphs; Weapons effects; Dosage; Physiological effects; Hemoglobin; Humans; Indicators; Laboratory animals; Reprints; Shallow depth; Slope; Tracking; Variables; Weapons; Carboxyhemoglobin; Dose-response relationships
Library   Call Number Additional Info Location Date Modified
NTIS AD-A221 043/3 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/27/1990
Collation 11p
Abstract Literature on dose-effects functions of carboxyhemoglobin (COHb) and human behavior is internally inconsistent. A recent study was performed to describe such a function for tracking behavior in humans. No significant effects were found, however, even for COHb levels up to ca. 17%. The present review and analysis of published data was undertaken to attempt to reduce uncertainty about COHb dose-effects functions. Dose-effects data from six laboratory animal operant behavior studies were reviewed. Maximum COHb levels ranged from 33 to 59%. Data were converted to a common metric and dose-effects functions were fitted. The preferred function was nonlinear, with a shallow slope, indicating small effects (if any) for COHb levels less than ca. 20%. As COHb increased further, the slope of the function became progressively steeper. Review of the human dose-effects function publications for COHb and behavior revealed that no significant findings had survived the test of direct or partial replication. Other studies found no significant effects. A dose-effects curve was fitted to the human data from one study and compared to the laboratory animal curves. Extrapolation of the human curve was used to suggest that the dose-effects curves for humans and laboratory animals were of similar form and that effects of COHb on behavior in man are small or absent below ca. 20%. It is also possible that some uncontrolled variables are affecting the results so that COHb produces effects only some of the time. No conclusion can be drawn from the body of literature due to the divergence of results. Keywords: Reprints, Weapons, Health and performance effects. (kr)
Supplementary Notes Pub. in Neurotoxicology and Teratology, v12 p111-118 1990.
NTIS Title Notes Final rept.
Title Annotations Reprint: Dose-Effects Functions for Carboxyhemoglobin and Behavior.
Category Codes 57B; 57T
NTIS Prices PC A03/MF A01
Document Type NT
Control Number 021101549
Cataloging Source NTIS/MT
Origin NTIS
Type CAT