OLS : Record


Main Title A short-term method for assessing the reproductive toxicity of endocrine-disrupting chemicals using the fathead minnow (Pimephales promelas) /
Author Mid-Continent Ecology Division.
CORP Author National Health and Environmental Effects Research Lab., Duluth, MN. Mid-Continent Ecology Div. (Duluth) Library.
Publisher National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Office of Research and Development, U.S. Environmental Protection Agency,
Place Published Duluth, MN
Year Published 2002
Report Number EPA/600/R-01/067
Stock Number PB2007-106215
OCLC Number 50549562
Subjects Reproductive toxicity; Assessment; Fathead minnow; Manuals; Test methods; Chemicals; Estrogens; Androgens; Endpoint; Reproductive behavior; Fecuncity; Fertility; Procedures; Measurements; Short-term test method; Endocrine-disrupting chemicals; Endocrine pathways; Adult survival; Secondary sex characteristics; Gonadosomatic; Gonadal histology; Plasma concentrations; Vitellogenin; Sex steroids
Subject Added Ent Endocrine disrupting chemicals--Toxicology.; Fathead minnow.; Reproductive toxicology.
Internet Access
Description Access URL
Library   Call Number Additional Info Location Date Modified
EIAD EPA/600/R-01/067 Region 2 Library/New York,NY 04/21/2006
EJAD EPA 600/R-01-067 Region 3 Library/Philadelphia, PA 06/18/2004
EJBD ARCHIVE EPA 600-R-01-067 Headquarters Library/Washington,DC 11/17/2015
EJBD EPA 600-R-01-067 Headquarters Library/Washington,DC 11/18/2015
EKCD EPA/600/R-01/067 NHEERL/GED Library/Gulf Breeze,FL 08/12/2013
ELDD EPA/600/R-01/067 3 copies NHEERL/MED Library/Duluth,MN 09/06/2002
NTIS PB2007-106215 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 10/08/2007
Collation xi, 154 pages : illustrations ; 28 cm
Abstract This manual describes a test method with the fathead minnow suitable for assessing potential reproductive effects of chemicals, with an emphasis on endocrine pathways controlled by estrogens and androgens. The test is conducted with reproductively-mature animals for 21 d. Endpoints assessed include: adult survival, reproductive behavior, secondary sex characteristics, gonadosomatic index, gonadal histology, plasma concentrations of vitellogenin and sex steroids (beta-estradiol, testosterone, 11-ketotestosterone), fecundity, fertility, and if desired, F(sub 1) viability. In addition to describing the test method, guidance is presented as to interpretation of test results with respect to identifican of potential endocrine-disrupting chemicals.
Notes "June 2002." Includes bibliographical references (pages 98-107). "EPA/600/R-01/067." Includes appendices "A-E" (p. 108-147).
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
Corporate Au Added Ent National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, (Duluth, Minn.)
PUB Date Free Form 2002
Category Codes 57Y
NTIS Prices PC A09/MF A02
BIB Level m
Medium unmediated
Control Number 019101430
OCLC Time Stamp 20151112121937
Cataloging Source OCLC/T
Language eng
Origin OCLC
OCLC Rec Leader 01504cam 2200337Ki 45020