OLS : Record


Main Title Acute and Subchronic Inhalation Exposures of Hamsters to Nickel-Enriched Fly Ash.
Author Wehner, Alfred P.; Moss, Owen R.; Milliman, Edward M.; Dagle, Gerald E.; Schirmer, Roger E.;
CORP Author Battelle Pacific Northwest Labs., Richland, WA. Biology Dept.;Health Effects Research Lab., Cincinnati, OH.
Year Published 1981
Report Number EPA-68-03-2457; EPA-600/J-79-125;
Stock Number PB81-201147
Subjects Fly ash; Toxicology; Nickel; Respiration; Exposure; Hamsters; Laboratory animals; Concentration(Composition); Aerosols; Lung; Reprints; Air pollution effects(Animals); Toxic substances; NTISEPAORD
Library   Call Number Additional Info Location Date Modified
NTIS PB81-201147 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 18p
Abstract One 6-hr inhalation exposure of hamsters to Ni-enriched fly ash (NEFA) aerosol (respirable aerosol concentration approx. 200 micrograms/liter) deposited about 80 micrograms in the deep lung, of which 75 micrograms was still present 30 days postexposure. The animals tolerated the exposure well during the 30-day postexposure observation period. Two-month exposures of hamsters to NEFA or fly ash (FA) aerosols (approx. 185 micrograms/liter) resulted in a deep lung burden of about 5.7 mg, dark discoloration of lungs, heavily dust-laden macrophages, and significantly higher lung weights than in controls, but only minimal inflammatory reaction and no deaths. There was no difference between NEFA and FA effects. The NEFA contained 9% Ni; FA contained 0.03% Ni. The results of this study indicate low acute and subchronic toxicity and slow lung clearance of NEFA and FA.
Supplementary Notes Pub. in Environmental Research 19, p335-370 1979.
NTIS Title Notes Journal article.
Title Annotations Reprint: Acute and Subchronic Inhalation Exposures of Hamsters to Nickel-Enriched Fly Ash.
PUB Date Free Form May 81
Category Codes 6T; 6F; 57Y; 68A
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Control Number 323798551
Cataloging Source NTIS/MT
Origin NTIS
Type CAT