Main Title |
Use of physiologically based pharmacokinetic models to quantify the impact of human age and interindividual differences in physiology and biochemistry pertinent to risk |
Other Authors |
|
Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, |
Year Published |
2006 |
Report Number |
EPA/600/R-06-14A ; 600R0614A |
OCLC Number |
66385721 |
Subjects |
Pharmacokinetics ;
Health risk assessment
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJBD |
EPA 600/R-06-14A |
|
Headquarters Library/Washington,DC |
04/14/2006 |
|
Collation |
{234} p. ; 28 cm. |
Notes |
EPA/600/R-06/014A "March 2006" Cooperative agreement: CR828047010. |
Contents Notes |
Incorporating human interindividual biotransformation variance in health risk assessment -- How differences in enzyme expression can translate into pharmacokinetic variance and susceptibility to toxicity -- Application of in vitro biotransformation data and pharmacokinetic modeling to risk assessment -- The impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome in humans -- Pharmacokinetic analysis to support an inhalation RfC for chloroform. |