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RECORD NUMBER: 299 OF 614Main Title | Initial Submission: Letter from (Confidential) to USEPA Reporting Preliminary Teratology Study of (Confidential), an Experimental Pyrethroid Insecticide in Rabbits, dated 1/25/2001 (Sanitized). | |||||||||||
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CORP Author | ; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
Year Published | 2001 | |||||||||||
Report Number | 8EHQ-0101-14856S | |||||||||||
Stock Number | OTS0560000 | |||||||||||
Additional Subjects | Toxicology ; Health effects ; Toxic substances ; Experimental pyrethroid insecticide | |||||||||||
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Collation | 8p | |||||||||||
Abstract | Confidiential was administered to pregnant rabbits in two groups (5 animals/dose level). Dosages were administered at 10, 50, 100, and 200 mg/kg to the primary group of animals. An additional grou of rabbits received 300 mg/kg to investigate further possible adverse effects of the test material. Doses were administered to both groups of rabbits during gestational days six through twenty- seven. A female of the primary group dosed with 200mg/kg developed clonic convulsions, a neurotoxic symptom, and subsequently died. The NOEL was, therefore, estimated to be lower than 200mg/kg. |