Main Title |
Computer Automated Structure Evaluation of Quinolone Antibacterial Agents. |
Author |
Klopman, G. ;
Macina, O. T. ;
Levinson, M. E. ;
Rosenkranz, H. S. ;
|
CORP Author |
Case Western Reserve Univ., Cleveland, OH. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1987 |
Year Published |
1987 |
Report Number |
EPA-R-812264; EPA/600/J-87/487; |
Stock Number |
PB90-111618 |
Additional Subjects |
Pharmacology ;
Tables(Data) ;
Reprints ;
Anti-infective agents ;
Quinolones ;
DNA gyrase ;
Computer automated structure evaluation(CASE) ;
Structure-activity relationship ;
Predictive value of tests
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-111618 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
The Computer Automated Structure Evaluation (CASE) program was used to study a series of quinolone antibacterial agents for which experimental data pertaining to DNA gyrase inhibition as well as MICs against several strains of gram-positive and gram-negative bacteria are available. The result of the analysis was the automatic generation of molecular fragments relevant to the respective biological endpoints. The potential significance of these major activating-inactivating fragments to the biological activity is discussed. (Copyright (c) 1987 American Society of Microbiology.) |