Record Display for the EPA National Library Catalog

RECORD NUMBER: 6 OF 9

OLS Field Name OLS Field Data
Main Title Effects of Low Dosage of Stable Strontium on Serum Enzymes in Chronic Alcoholics.
Author Stara, J. F. ; Perras, J. ; Pivon, R. J. ; Koch, P. ; Nolan, J. T. ;
CORP Author Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. ;McGill Univ., Montreal (Quebec). ;La Maison Jean Lapointe, Montreal (Quebec).
Publisher c1986
Year Published 1986
Report Number EPA/600/D-89/032;
Stock Number PB89-223911
Additional Subjects Strontium compounds ; Alcoholism ; Enzymes ; Blood ; Mitochondria ; Dosage ; Glucosephosphate dehydrogenase ; Atomic absorption spectrophotometry ; GGTP
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB89-223911 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/18/1989
Collation 20p
Abstract
The study shows the systemic effects of low dosage of stable Sr(2+) in relation to chronic ethanol abuse. In the current study, 6 chronic alcoholic patients were administered Sr carbonate (600-700 mg of Sr(2+) per day) for periods of 4-6 weeks, alternating with treatment-free (placebo) intervals. Serum GDH was determined using Koch's modification; GGTP was determined using standard methodology (Gilford Stasar III). Serum ethanol levels were determined using Alcohol Dipstick Methodology of Kapur and Israel. Serum Sr(2+) and Ca(2+) levels were determined by Atomic Absorption Spectrophotometry. In patients receiving Sr(2+), serum GDH levels were decreased 61-68% (range 44.9-88.6%) when compared to the control periods during the acute alcoholic episodes. The effects of Sr(2+) on serum GGTP levels varied in extent of decrease. The preliminary studies indicate that low dosage of Sr(2+) exerts a protective effect on mitochondrial function during acute alcoholic episodes.