||Mutagenicity Evaluation of Unleaded Gasoline. Final Report.
||Litton Bionetics, Inc., Kensington, MD. ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Chemical compounds ;
Microbial assays ;
Bone marrow ;
In vitro analysis ;
In vivo analysis ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Unleaded Gasoline was evaluated for mutgenic potential and germinal cell risk in a three-tier testing approach. The first tier consisted of in vitro microbial assays in which the test chemical was screened for mutagenic and recombinogenic activity using bacteria Salmonella typhimurium and yeast (Saccharomyces cerevisiae) in both plate and suspension techniques. The second tier consisted of screening the compound for mutation induction to cultured Mammalian cells (L5178Y, TK +/-) in vitro. The third tier consisted of an in vivo cytogenetic analysis of rat bone marrow cells.