||Interaction between methyl mercury and radiation effects on nervous systems /
Hupp, Eugene W. ;
Day, Dalton ;
Hardcastle, James ;
Hines, John ;
||Texas Woman's Univ., Denton.;Health Effects Research Lab., Research Triangle Park, N.C. Experimental Biology Div.
|| U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
||PB 265 873
Methylmercuric chloride--Physiological effect ;
Radiation--Physiological effect ;
Rats--Effect of radiation on ;
Hamsters--Effect of radiation on ;
Monkeys--Effect of radiation on
Radiation effects ;
Nervous system ;
Laboratory animals ;
Experimental data ;
X rays ;
Synergistic effects ;
Air pollution effects(Animals) ;
||Region 3 Library/Philadelphia, PA
||Research Triangle Park Library/RTP, NC
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||xii, 118 p. ; 28 cm.
The interaction between methyl mercury and ionizing radiation was investigated in a series of experiments using rats, hamsters, and squirrel monkeys to study the effects produced and possible mechanisms of action. Parameters evaluated included several measurements of behavior, brain electrical activity, lethality, blood-brain barrier permeability, neurotransmitter and mercury concentration in various brain areas, and brain histology. In some cases the effects of the co-insult were less than or at least no greater than at least one of the two insults applied alone. Possible mechanisms of action include opposite effects of the two insults on the blood-brain barrier, with radiation increasing permeability and methyl mercury decreasing it. Radiation may also elicit a proliferation of peroxisome-like organelles which protect against the effects of methyl mercury.
Project Officer: Daniel F. Cahill. Texas Woman's University "January 1977." "EPA-600/1-77-006." Includes bibliographical references.