Record Display for the EPA National Library Catalog

RECORD NUMBER: 36 OF 107

OLS Field Name OLS Field Data
Main Title Interaction between methyl mercury and radiation effects on nervous systems /
Author Hupp, Eugene W. ; Day, Dalton ; Hardcastle, James ; Hines, John ; Minnich., James
Other Authors
Author Title of a Work
Hupp, Eugene W.
Cahill, Daniel F.
CORP Author Texas Woman's Univ., Denton.;Health Effects Research Lab., Research Triangle Park, N.C. Experimental Biology Div.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1977
Report Number EPA-600/1-77-006; EPA-R-800282
Stock Number PB 265 873
OCLC Number 52418631
Subjects Methylmercuric chloride--Physiological effect ; Radiation--Physiological effect ; Rats--Effect of radiation on ; Hamsters--Effect of radiation on ; Monkeys--Effect of radiation on
Additional Subjects Radiation effects ; Nervous system ; Neurology ; Toxicology ; Laboratory animals ; Experimental data ; Rats ; Hamsters ; Monkeys ; Physiology ; Histology ; Brain ; Behavior ; X rays ; Stress(Physiology) ; Synergistic effects ; Mercury/methyl ; Air pollution effects(Animals) ; Environmental health
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=2000Y5A6.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJAD  EPA 600/1-77-006 Region 3 Library/Philadelphia, PA 11/21/2011
EJBD ARCHIVE EPA 600-1-77-006 Headquarters Library/Washington,DC 11/01/2010
EJBD  EPA 600-1-77-006 Headquarters Library/Washington,DC 01/17/2014
EKBD  EPA-600/1-77-006 Research Triangle Park Library/RTP, NC 06/13/2003
NTIS  PB-265 873 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation xii, 118 p. ; 28 cm.
Abstract
The interaction between methyl mercury and ionizing radiation was investigated in a series of experiments using rats, hamsters, and squirrel monkeys to study the effects produced and possible mechanisms of action. Parameters evaluated included several measurements of behavior, brain electrical activity, lethality, blood-brain barrier permeability, neurotransmitter and mercury concentration in various brain areas, and brain histology. In some cases the effects of the co-insult were less than or at least no greater than at least one of the two insults applied alone. Possible mechanisms of action include opposite effects of the two insults on the blood-brain barrier, with radiation increasing permeability and methyl mercury decreasing it. Radiation may also elicit a proliferation of peroxisome-like organelles which protect against the effects of methyl mercury.
Notes
Project Officer: Daniel F. Cahill. Texas Woman's University "January 1977." "EPA-600/1-77-006." Includes bibliographical references.