Record Display for the EPA National Library Catalog

RECORD NUMBER: 37 OF 70

OLS Field Name OLS Field Data
Main Title Inhalable Particles and Pulmonary Host Defense: 'In vivo' and 'In vitro' Effects of Ambient Air and Combustion Particles.
Author Hatch, G. E. ; Boykin, E. ; Graham, J. A. ; Lewtas, J. ; Pott, F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;Duesseldorf Univ. (Germany, F.R.).
Year Published 1985
Report Number EPA/600/J-85/026;
Stock Number PB85-198877
Additional Subjects Air pollution ; In vivo analysis ; In vitro analysis ; Toxicity ; Bioassay ; Laboratory animals ; Bacteria ; Industrial wastes ; Combustion products ; Exhaust emissions ; X ray analysis ; Pulmonary diseases ; Electric power plants ; Fly ash ; Fluidized bed processing ; Particles ; Metals ; Reprints ; Air pollution effects(Animals) ; Cytotoxicity
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-198877 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 15p
Abstract
The ability of particulate air pollutants (and possible constituents) to alter pulmonary host defenses was examined using an in vitro alveolar macrophage cytotoxicity assay and an in vivo bacterial infectivity screening test which employed intratracheal injection of the particles. A wide range of response between particles was seen at the 1.0 mg/ml level in vitro and the 0.1 mg/mouse level in vivo. A sample of fluidized-bed coal fly ash, bentonite, asbestos, some ambient air particles and heavy metal oxides greatly increased susceptibility to pulmonary bacterial infection. Most coal fly ash samples and some air particles caused moderate increases in infectivity, while diesel particulates, volcanic ash, and crystalline silica caused only small increases. Cytotoxic effects on macrophages in vitro were observed with most of the particles. The in vivo and in vitro assays produced a similar ranking of toxicity, however, not all particles that were highly cytotoxic were potent in increasing bacterial infectivity. Increased toxicity measurable by either assay often appeared to be associated with small size or with the presence of metal in the particles. (Copyright (c) 1985 by Academic Press, Inc.)