||Application of benchmark dose methodology to data from prenatal developmental toxicity studies.
Kimmel, C. A. ;
Kavlock, R. J. ;
Allen, B. C. ;
Faustman, E. M.
||Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment. ;Washington Univ., Seattle. Dept. of Environmental Health. ;ICF Kaiser, Research Triangle Park, NC.
|| National Risk Management Research Laboratory,
Risk assessment ;
Dose-response relationships ;
Fetal development ;
Weight measurement ;
Experimental data ;
Statistical analysis ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The benchmark dose (BMD) concept was applied to 246 conventional developmental toxicity datasets from government, industry and commercial laboratories. Five modeling approaches were used, two generic and three specific to developmental toxicity (DT models). BMDs for both quantal and continuous data were compared with statistically-derived NOAELs (NOSTASOTs) to determine similarities. Quantal (Q) endpoints included litter responses (e.g., one or more dead or malformed implants), and QBMDs were calculated using a quantal Weibull (QW) model. Two types of continuous (C) data were modeled, the proportion of implants affected per litter, and the change in fetal weight (both mean and distribution); continuous power (CP) and DT models were used to calculate CBMDs. The results support the use of BMDs as providing a more consistent basis for risk assessment than do NOAELs.
"July 1995." "NCEA-W-017." "PB96-117536."