Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Hexachlorophene Effects on the Rat Brain, Study of High Doses by Light and Electron Microscopy.
Author Kimbrough, Renate D. ; Gaines., Thomas B. ;
CORP Author Food and Drug Administration, Chamblee, Ga.
Year Published 1970
Stock Number PB-280 831
Additional Subjects Toxicology ; Bactericides ; Pesticides ; Fungicides ; Bioassay ; Rats ; Brain ; Physiological effects ; Dosage ; Electron microscopy ; Laboratory animals ; Concentration(Composition) ; Dosage ; Ingestion(Biology) ; Diets ; Weight(Mass) ; Experimental data ; Pathology ; Central nervous system ; Toxicity ; Reprints ; Hexachlorophene ; Brain edema ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB-280 831 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 6p
Hexachlorophene was fed to female adult Sherman strain rats at 500 ppm (25 mg/kg/day) for 14 and 10 weeks in two consecutive studies. After two weeks on the diet containing hexachlorohene, the rats developed leg weakness which progressed to paralysis in three to five weeks. After ten weeks on these diets in the second study, hexachlorophene was discontinued; the rats regained almost complete recovery of leg function within six weeks. The brains of the rats that had ingested hexachlorophene weighed significantly more than those of controls and returned to normal in six weeks. The lesions produced by hexachlorophene in the rat brains represented cerebral edema limited to the white matter, which resembles diffuse spongy deggeneration of the white matter of the brain described in infants.