||Use of Short-Term Bioassays in Estimating Human Health Hazards of Wastewater Effluents.
Condie, L. W. ;
Easterly, C. E. ;
Glass, L. R. ;
||Health Effects Research Lab., Cincinnati, OH. Toxicology and Microbiology Div. ;Oak Ridge National Lab., TN. Health and Safety Research Div.
Hazardous materials ;
Chemical effluents ;
Water pollution detection ;
Toxic substances ;
Risk assessment ;
Health effects ;
Health hazards ;
Wastewater treatment facilities
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Effluents from wastewater treatment facilities are discharged as a complex mixture of numerous chemical substances, which may include cytotoxic, carcinogenic and mutagenic compounds. The U.S. Environmental Protection Agency has recently established a research program to determine if a bioassay approach for evaluating the potential adverse human health effects from exposure to complex mixtures might supplement conventional chemical analysis for setting regulatory limits for wastewaters. The paper summarizes a bioassay testing strategy for characterizing cytotoxic and mutagenic activity of various wastewater effluents. The use of a relative potency framework for assessing complex mixtures for potential health hazards is addressed.