Section I - Microglia and CNS Disease -- 1. Microglia: a CNS-Specific Tissue Macrophage -- Shweta S. Puntambekar, Jonathan M. Doose, Monica J Carson -- 2. Mechanisms of Microglial Activation by Amyloid Precursor Protein and its Proteolytic Fragments -- S. A. Austin and C. K. Combs -- 3. Pericytes -- Martin Krüger and Ingo Bechmann -- 4. Imaging Microglia in the Central Nervous System: Past, Present, and Future -- Dimitrios Davalos and Katerina Akassoglou -- Section II - Innate Immune Responses within the Brain -- 5. Cytokines in CNS inflammation and disease -- Malú G. Tansey and Tony Wyss-Coray -- 6. Arachidonic acid metabolites: Function in neurotoxicity and inflammation in the central nervous system -- and T.J. Montine -- 7. Pattern Recognition Receptors in CNS Disease -- Pamela A. Carpentier, D'Anne S. Duncan, Stephen D. Miller -- 8. The Complement System in the CNS: Thinking again -- Andrea J. Tenner and Karntipa Pisalyaput -- Section III - Chemokines and CNS Disease -- 9. Chemokines and autoimmune demyelination -- Michaela Fux, Jason Millward, and Trevor Owens -- 10. Chemokine actions in the CNS: Insights from transgenic models -- Marcus Müller and Iain L. Campbell -- 11. Chemokines and Spinal Cord Injury -- Maya N. Hatch and Hans S. Keirstead -- 12. The Usual Suspects: Chemokines and Microbial Infection of the Central Nervous System -- Michelle J. Hickey, Linda N. Stiles, Chris S. Schaumburg, and Thomas E. Lane -- Section IV - Antigen Presentation and Immune Responses within the Brain -- 13. CNS Dendritic Cells in Inflammation and Disease -- Samantha L. Bailey and Stephen D. Miller -- 14. MHC class I Expression and CD8+ T Cell Function: Towards the Cell Biology of T-APC Interactions in the Infected Brain -- Cornelia Bergmann and Pedro Lowenstein. This volume serves as a succinct and well-organized reference volume focused on inflammatory CNS disease to a wide audience. The text is comprised of four sections revolving around current areas of interest in the fields of neuroimmunology, virology, pharmacology and disease. Sections of this text focus on a specific category of diseases as well as the pharmacological, virological, and immunological effects of and on the disease. Although many have covered this topic, few have provided a volume as concise and efficient. Each disease is broken down on a variety of scientific levels without getting into the history of the disease. This approach provides a succinct overview of a specific subject encompassing interrelated topics pertaining to neurology, immunology and disease. The information provided in Central Nervous System Diseases and Inflammation will be useful for researchers, clinicians, as well as a valuable resource for students interested in the fascinating arena of neuroinflammation.