Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Bacterial Virulence Factors and Rho GTPases [electronic resource] /
Author Boquet, Patrice.
Other Authors
Author Title of a Work
Lemichez, Emmanuel.
Publisher Springer Berlin Heidelberg,
Year Published 2005
Call Number QR355-502
ISBN 9783540275114
Subjects Medicine. ; Medical virology.
Internet Access
Description Access URL
Collation X, 198 p. 28 illus. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Bacterial Virulence Strategies That Utilize Rho GTPases -- Extracellular Bacterial Pathogens and Small GTPases of the Rho Family: An Unexpected Combination -- Triggered Phagocytosis by Salmonella: Bacterial Molecular Mimicry of RhoGTPase Activation/Deactivation -- Regulation of Phagocytosis by Rho GTPases -- The Immunological Synapse and Rho GTPases -- Rho GTPases and the Control of the Oxidative Burst in Polymorphonuclear Leukocytes -- Clostridial Rho-Inhibiting Protein Toxins -- The Type III Cytotoxins of Yersinia and Pseudomonas aeruginosa That Modulate the Actin Cytoskeleton -- Modulation of Rho GTPases and the Actin Cytoskeleton by YopT of Yersinia -- Bacterial Toxins Activating Rho GTPases. Pathogenic bacteria for human and animals have developed sophisticated weapons, termed virulence factors, to ensure their replication and persistence into their hosts. The first role of these virulence factors is to loosen the host defenses against microorganisms represented by innate and adaptive immunities. Small GTPases of the Rho subfamily have been shown top play important functions in theses systems. The authors of this volume present the synthesis on how the various host cellular Rho GTPases activities are manipulated by bacteria to fulfill their virulence.