Record Display for the EPA National Library Catalog

RECORD NUMBER: 551 OF 1744

OLS Field Name OLS Field Data
Main Title Evaluating the Toxicity of Urban Patterns of Oxidant Gases. 2. Effects in Mice from Chronic Exposure to Nitrogen Dioxide.
Author Miller, F. J. ; Graham, J. A. ; Raub, J. A. ; Illing, J. W. ; Menache, M. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/097;
Stock Number PB88-139969
Additional Subjects Toxicology ; Nitrogen ; Urban areas ; Exposure ; Mice ; Laboratory animals ; Bioassay ; Reprints ; Air pollution effects
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB88-139969 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 16p
Abstract
The study reported herein evaluates the influence of a chronic exposure to an urban pattern of NO2 (continuous baseline exposure of 0.2 ppm on which were superimposed two 1-hr spikes of 0.8 ppm NO2, 5 days/wk) as compared to the baseline exposure to determine the contribution of the spikes to toxicity. Mice were exposed for up to 52 wk with interim examinations. Multivariate analysis of variance revealed a statistically significant treatment effect on infectivity (p=0.05) and pulmonary function (p=0.03) parameters. Infectivity mortality of mice in the spiked exposure regimen was significantly greater than that in either the NO2-background exposed mice or in control mice. Four of the pulmonary function variables exhibited the greatest differences among the treatment groups: end expiratory volume, vital capacity, respiratory system compliance, and multiple-breath nitrogen washout. Results from the pulmonary function analyses indicate that the spiked exposures to 0.8 ppm NO2 may have induced a subtle lesion. The chronic study results indicate that the presence of spikes of NO2 is contributing significantly to effects on antibacterial lung defenses and pulmonary function of mice.