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RECORD NUMBER: 194 OF 489

OLS Field Name OLS Field Data
Main Title Fish Acute Toxicity Syndromes: Application to the Development of Mechanism-Specific QSARS (Quantitative Structure Activity Relationships).
Author Bradbury, S. P. ;
CORP Author Environmental Research Lab.-Duluth, MN.
Year Published 1988
Report Number EPA/600/D-88/115;
Stock Number PB88-214762
Additional Subjects Water pollution ; Toxicology ; Aquatic biology ; Trout ; Mathematical models ; Information systems ; Narcotics ; Cardiovascular system ; Respiratory system ; Industrial wastes ; Hazardous materials ; Cholinesterase inhibitors ; Toxic substances ; Salmo gairdneri
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB88-214762 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/29/1988
Collation 14p
Abstract
Predictive models based on quantitative structure activity relationships (QSARs), are used as rapid screening tools to identify potentially hazardous chemicals. Several QSARs are now available that predict the acute toxicity of narcotic-industrial chemicals. Predictions for compounds acting through more specific modes of action, which are generally more toxic, require alternative models. Current efforts are focused on characterizing a toxic mode of action database from which the structural requirements for specific mechanisms can be elucidated. Approaches include application of joint toxicity theory for chemical mixtures and the assessment of fish acute toxicity syndromes, that is, distinct sets of in vivo rainbow trout (Salmo gairdneri) toxic responses that correspond to specific modes of action. By measuring a number of respiratory-cardiovascular variables, response sets associated with nonpolar and polar narcotics, oxidative phosphorylation uncouplers, respiratory membrane irritants, respiratory inhibitors, acetylcholinesterase inhibitors, and central nervous system seizure agents have been described.