Record Display for the EPA National Library Catalog

RECORD NUMBER: 129 OF 488

OLS Field Name OLS Field Data
Main Title Effect of Carbon Tetrachloride Treatment on Urine Flow Rate of the Rainbow Trout, 'Salmo gairdneri'.
Author Pfeifer, K. F. ; Weber, L. J. ;
CORP Author Oregon State Univ., Newport. Marine Science Center.;Environmental Research Lab.-Duluth, MN.
Year Published 1980
Report Number EPA-R-803090; EPA-600/J-80-435;
Stock Number PB84-117431
Additional Subjects Toxicology ; Carbon tetrachloride ; Chlorine organic compounds ; Urine ; Concentration(Composition) ; Fishes ; Reprints ; Water pollution effects(Animals) ; Rainbow trout ; Salmo gairdneri
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB84-117431 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 7p
Abstract
Urine flow rate (UFR) of rainbow trout was measured as an assessment of water balance after treatment with a single ip dose of CC14 (2.0 ml/kg). CC14 produced an oliguria or anuria as early as 1 hr post-treatment and a significant reduction in the 24-hr urine output. UFR for control fish appeared to follow a diurnal pattern. Additionally, CC14-treated fish had a significant increase in relative wet body weight that was negatively correlated to UFR. The rainbow trout normally excretes a hypoosmotic urine; therefore, an increase in urine osmolality and a slight proteinuria further suggested that treated fish had suffered an alteration in renal homeostasis. Histological examination of kidney tissue at 24 hr post-treatment revealed early, localized pathological changes; however, extensive morphological damage was absent. The early oliguria and the lack of demonstrable renal histopathological changes in CC14-treated rainbow trout suggest that the reduction in UFR was not the result of a direct toxic effect on the kidney.