||Effect of Carbon Tetrachloride Treatment on Urine Flow Rate of the Rainbow Trout, 'Salmo gairdneri'.
Pfeifer, K. F. ;
Weber, L. J. ;
||Oregon State Univ., Newport. Marine Science Center.;Environmental Research Lab.-Duluth, MN.
Carbon tetrachloride ;
Chlorine organic compounds ;
Water pollution effects(Animals) ;
Rainbow trout ;
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Urine flow rate (UFR) of rainbow trout was measured as an assessment of water balance after treatment with a single ip dose of CC14 (2.0 ml/kg). CC14 produced an oliguria or anuria as early as 1 hr post-treatment and a significant reduction in the 24-hr urine output. UFR for control fish appeared to follow a diurnal pattern. Additionally, CC14-treated fish had a significant increase in relative wet body weight that was negatively correlated to UFR. The rainbow trout normally excretes a hypoosmotic urine; therefore, an increase in urine osmolality and a slight proteinuria further suggested that treated fish had suffered an alteration in renal homeostasis. Histological examination of kidney tissue at 24 hr post-treatment revealed early, localized pathological changes; however, extensive morphological damage was absent. The early oliguria and the lack of demonstrable renal histopathological changes in CC14-treated rainbow trout suggest that the reduction in UFR was not the result of a direct toxic effect on the kidney.