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RECORD NUMBER: 27 OF 307

OLS Field Name OLS Field Data
Main Title Consideration of the Target Organ Toxicity of Trichloroethylene in Terms of Metabolite Toxicity and Pharmacokinetics.
Author Davidson, I. W. F. ; Beliles, R. P. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. ;Bowman Gray School of Medicine, Winston-Salem, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/238 ;OHEA-C-466;
Stock Number PB92-198621
Additional Subjects Trichloroethylene ; Toxicity ; Pharmacokinetics ; Metabolism ; Laboratory animals ; Dose-response relationships ; Environmental exposure pathways ; Biotransformation ; Urine ; Humans ; Mutagens ; Carcinogens ; Liver ; Lung ; Kidney ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB92-198621 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/01/1993
Collation 108p
Abstract
Trichloroethylene (TRI) is readily absorbed into the body through the lungs and gastrointestinal mucosa. Exposure to TRI can occur from contamination of air, water, and food; and the contamination may be sufficient to produce adverse effects in the exposed populations. Elimination of TRI involves two major processes: pulmonary excretion of unchanged TRI and relatively rapid hepatic biotransformation to urinary metabolites. The principal site of metabolism of TRI is the liver, but the lung and possibly other tissues also metabolize TRI, and dichlorvinyl-cysteine (DCVC) is formed in the kidney. The toxicities associated with TRI exposure are considered to reside in its reactive metabolites. The mutagenic and carcinogenic potential of TRI is also generally thought to be due to reactive intermediate biotransformation products rather than the parent molecule itself.