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RECORD NUMBER: 21 OF 92

OLS Field Name OLS Field Data
Main Title Chlorothene Vg: a Chronic Inhalation Toxicity and Oncogenicity Study in Rats and Mice (part 1 & 2) with Cover Letter dated 08/21/1984.
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1984
Report Number 40-8424496
Stock Number OTS0510656
Additional Subjects Toxicology ; Health effects ; 1 ; 1 ; 1-trichloroethane ; Chronic Toxicity ; Combined Chronic Toxicity/carcinogenicity ; Mammals ; Rats ; Inhalation ; Mice ; Biochemistry ; Toxic substances ; Laboratory animals ; CAS No 71-55-6
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NTIS  OTS0510656 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 290p
Abstract
Chronic toxicity and oncogenicity were evaluated in groups of male and female Fischer 344 rats (80/sex/group) exposed to chlorothene (1,1,1-trichloroethane) by inhalation at 0, 150, 500, or 1500 ppm for 6 hrs/day, 5 days/week for 2 years. The body weights of female animals were significantly decreased compared to controls at various times throughout the study, whereas relative and absolute organ weights were unaffected. The hematology, urinalysis, and clinical chemistry values were unaffected by the treatments. Necropsy of animals sacrificed at 6, 12 and 18 months of exposure revealed no significant exposure-related effects and there were no significant differences in the incidence of tumor-like lesions in the control or exposed rats. Microscopic examination of the livers of animals exposed to 1500 ppm revealed an exposure-related accentuation of the normal hepatic lobular pattern consisting of altered cytoplasmic staining in the cells surrounding the central vein. Chronic toxicity and oncogenicity were also evaluated in groups of 80 male and 80 female B6C3F1 miceexposed to chlorothene in the same manner as above. The body weights of both males and females in all exposure groups were comparable to the controls. All other findings correlated to those described above for rats.