Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title The pharmacodynamics of certain endogenous mammalian antioxidants during NO2 exposure /
Author Lunan, Kenneth D. ; Brandt., Alan E.
Other Authors
Author Title of a Work
Brandt, Alan E.
Goldstein, George M.
CORP Author Stanford Research Inst., Menlo Park, Calif. Environmental Biochemistry Lab.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1976
Report Number EPA-600/1-76-028; EPA-68-02-1713; PB263910
Stock Number PB 263 910
OCLC Number 52418667
Subjects Nitrogen dioxide--Pharmacokinetics. ; Ozone.
Additional Subjects Tocopherol ; Antioxidants ; Nitrogen dioxide ; Vitamins ; Pharmacology ; Air pollution ; Ozone ; Metabolism ; Fatty acids ; Oxidation ; Lipids ; Enzymes ; Transferases ; Liver ; Lung ; Blood ; Rats ; Laboratory animals ; Quinones ; Tocopheronolactone glucuronosyltransferase
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EIAD  EPA-600/1-76-028 Region 2 Library/New York,NY 06/27/2003 DISPERSAL
EJBD ARCHIVE EPA 600-1-76-028 Headquarters Library/Washington,DC 04/30/2012
EJBD  EPA 600-1-76-028 Headquarters Library/Washington,DC 04/08/2014
EKBD  EPA-600/1-76-028 Research Triangle Park Library/RTP, NC 06/13/2003
NTIS  PB-263 910 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation xi, 57 p. : ill. ; 28 cm.
The predominant theory for vitamin E action is based on the antioxidant properties of the vitamin. Vitamin E prevents the peroxidation of polyunsaturated fatty acids found in lipids of cellular membranes, thereby stabilizing membrane structure. This action is demonstrated by the marked fragility of red blood cells of animals deficient in vitamin E. Lipid peroxidation is initiated by exposure to hyperbaric oxygen and other oxidizing atmospheres such as nitrogen dioxide (NO2) and ozone (O3). Vitamin E is believed to quench highly toxic free radicals generated during peroxidation, thus terminating the free radical chain reaction. This report describes studies on the effect of NO2 on the retention of 14C-alpha-tocopherol in lungs, liver, and blood and on the formation and disposition of alpha-tocopherol and retinol oxidation products. Also presented are initial results on the characterization of one of the enzymes involved in alpha-tocopherol metabolism, UDP-glucuronic acid: alpha-tocopheronolactone glucuronosyl transferase.
"Project officer, George M. Goldstein." "EPA-600/1-76-028." "August 1976." Includes bibliographical references (p. 51-56). Stanford Research Institute