||Statistical methods for estimating risk for exposure above the reference dose /
Knauf, Linda A. ;
Hertzberg, R. C.
||Computer Sciences Corp., Cincinnati, OH.;Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.
|| U.S. Environmental Protection Agency, Office of Research and Development, Environmental Criteria Assessment,
Environmental toxicology. ;
Dose-response relationship (Biochemistry) ;
Statistical analysis ;
Regression analysis ;
Mathematical models ;
Risk assessment ;
Environmental pollution ;
Dose-response relationships ;
Computer applications ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||104 pages ; 28 cm
A statistical method has been developed that provides a risk estimate for noncarcinogenic effects at a given dose. The method uses a categorical regression procedure to model severity of effect as it relates to experimental dose. Toxicity data are analyzed from multiple animal experiments that span different species, target organs, toxic effects, and exposure conditions. The data are screened for homogeneity with respect to experiment duration and route of exposure. The resulting dose-response curve provides an estimate of the risk of adverse effects that may be useful in estimating risk for exposures above the reference dose (RfD).
Caption title. "EPA/600/8-90/065." "August 1990." Includes bibliographical references. Microfiche.