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RECORD NUMBER: 9 OF 112

OLS Field Name OLS Field Data
Main Title Behavioral Toxicity of Trialkyltin Compounds: A Review.
Author Reiter, L. W. ; Ruppert, P. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/D-84-012;
Stock Number PB84-130426
Additional Subjects Toxicity ; Tin organic compounds ; Behavior ; Reviews ; Laboratory animals ; Exposure ; Dosage ; Neurology ; Humans ; Toxic diseases ; Public health ; Industrial hygiene ; Toxic substances ; Air pollution effects(Humans) ; Occupational safety and health ; Tin/triethyl ; Tin/trimethyl ; Neurotoxicity
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB84-130426 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 22p
Abstract
Triethyltin (TET) and trimethyltin (TMT) are neurotoxic organotin compounds which produce different patterns of toxicity in adult animals. Exposure to TET produces behavioral toxicity (decreased motor activity, grip strength, operant response rate and startle response amplitude) which reflects impaired neuromotor function. These deficits are consistent with the reported myelin vacuolation and cerebral edema produced by TET, and with its direct effects on muscle. Exposure to TMT produces both hyperactivity and impaired learning and performance. These impairments are consistent with reported neuronal cell death produced by TMT, particularly in limbic system structures. While the behavioral deficits produced by repeated exposure to TET are reversible when dosing is terminated, the behavioral impairment produced by a single exposure TMT appears to be irreversible.