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RECORD NUMBER: 12 OF 59

OLS Field Name OLS Field Data
Main Title Comparison of Bioindicators of Exposure to Genotoxic Indoor Air Pollutants.
Author Lewtas, J. ; Gallagher., J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1990
Year Published 1990
Report Number EPA/600/D-90/166;
Stock Number PB91-132977
Additional Subjects Mutagens ; Exposure ; Chemical analysis ; Body fluids ; Salmonella typhimurium ; Indoor air pollution ; Air pollution effects(Humans) ; Environmental monitoring ; Mutagenicity tests ; Tobacco smoke pollution ; DNA damage ; Cotinine ; Nicotine ; Urinalysis
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-132977 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/04/1991
Collation 11p
Abstract
Human exposure to complex mixtures of genotoxic indoor air pollutants can be assessed using several different bioanalytical methods. External exposure can be assessed using micromutagenesis methods to measure human exposure to mutagens. Internal exposure and dose can be assessed using macromolecular adducts (e.g., DNA adducts). Urinary metabolites of specific components and the mutagenicity of urine have also been used as bioindicators of exposure. External exposure to the mutagenic activity of tobacco smoke is readily measured indoors and results in the highest reported exposure to mutagens. External exposure to mutagens from ETS has been compared to internal exposure by using urinary measurements of the nicotine metabolite, cotinine. The organic matter (tar) from particles emitted from tobacco smoke and other combustion sources is genotoxic to cells, carcinogenic to animals, and results in the formation of DNA adducts.