Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EHAM |
QP82.2.P6E2 600, 1980, no.31 |
|
Region 1 Library/Boston,MA |
04/29/2016 |
EJBD |
EPA 600-3-80-031 |
|
Headquarters Library/Washington,DC |
04/01/2016 |
EKBD |
EPA-600/3-80-031 |
|
Research Triangle Park Library/RTP, NC |
07/18/2003 |
ELBD ARCHIVE |
EPA 600-3-80-031 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ESAD |
EPA 600-3-80-031 |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
NTIS |
PB80-177868 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Abstract |
The effects of the subacute doses of Dimilin (1(4-chlorophenyl)-3-(2,6-difluoropbenzyl)urea) on the reproductive system of weanling male rats were examined over a period of 96 days. The parameters evaluated were: plasma testosterone level, growth of reproductive organs (testes, prostate, seminal vesicles) and adrenal glands, and histological examination of tissues for pathological changes associated with the administration of Dimilin. The animals, 25 days old, were given 0, 15, 150, and 300 milligrams/kilogram/day of Dimilin suspension in vegetable oil by intragastric intubation for a period of 0, 14, 28, 42, and 96 days. The data indicate that Dimilin had no adverse effects on body weight or organ weights of weanling rats, but a decrease in circulating testosterone in the plasma of animals of prepubertal age was noted. However, this effect of Dimilin began to disappear with the onset of puberty. The histological examination of the test animals with lower circulating testerone in plasma failed to reveal any Dimilin-induced changes in interstitial or germinal cells. On the basis of these observations, it is concluded that Dimilin, at 15, 150, and 300 mg/kg/day dosage levels, transiently depresses the testosterone in plasma in the prepubertal period, yet has no delaying effects on the development of the reproductive organs. |