Record Display for the EPA National Library Catalog

RECORD NUMBER: 2 OF 3

OLS Field Name OLS Field Data
Main Title Assessment of thyroid follicular cell tumors /
CORP Author Environmental Protection Agency, Washington, DC. Risk Assessment Forum.
Publisher U.S. Environmental Protection Agency, Risk Assessment Forum,
Year Published 1998
Report Number EPA/630/R-97/002; "NCEA-F-0382."
Stock Number PB98-157860
Subjects Thyroid gland--Tumors. ; Health risk assessment.
Additional Subjects Thyroid neoplasms ; Dose-response relationships ; Risk assessment ; Infants ; Children ; Follicular phase ; Carcinogens ; Hazardous materials ; Health hazards ; Tumors ; Cells(Biology) ; Toxicology
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=30004ZHZ.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB98-157860 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 218 pages : illustrations ; 23 cm
Abstract
The Report presents science policy guidance that describes the procedures the Agency will use in the evaluation of potential human cancer hazard and dose-response assessments from chemicals that are animal thyroid carcinogens. The Forum Report describes when, under clearly specified conditions, chemical carcinogenesis in thyroid follicular cells can be analyzed as a nonlinear phenomenon, rather than assuming low dose linearity as EPA customarily does for carcinogenic compounds. Four hypothetical cases are summarized which illustrate how to evaluate toxicological data and make hazard and dose-response estimation choices. The procedures and considerations developed in the Forum Report embody currenty scientific knowledge of thyroid carcinogenesis and evolving science policy.
Notes
"EPA/630/R-97/002." "March 1998." "Risk Assessment Forum." "Supercedes PB98-133119." Microfiche.