||Assessment of thyroid follicular cell tumors /
||Environmental Protection Agency, Washington, DC. Risk Assessment Forum.
|| U.S. Environmental Protection Agency, Risk Assessment Forum,
Thyroid gland--Tumors. ;
Health risk assessment.
Thyroid neoplasms ;
Dose-response relationships ;
Risk assessment ;
Follicular phase ;
Hazardous materials ;
Health hazards ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||218 pages : illustrations ; 23 cm
The Report presents science policy guidance that describes the procedures the Agency will use in the evaluation of potential human cancer hazard and dose-response assessments from chemicals that are animal thyroid carcinogens. The Forum Report describes when, under clearly specified conditions, chemical carcinogenesis in thyroid follicular cells can be analyzed as a nonlinear phenomenon, rather than assuming low dose linearity as EPA customarily does for carcinogenic compounds. Four hypothetical cases are summarized which illustrate how to evaluate toxicological data and make hazard and dose-response estimation choices. The procedures and considerations developed in the Forum Report embody currenty scientific knowledge of thyroid carcinogenesis and evolving science policy.
"EPA/630/R-97/002." "March 1998." "Risk Assessment Forum." "Supercedes PB98-133119." Microfiche.