Record Display for the EPA National Library Catalog
RECORD NUMBER: 82 OF 108Main Title | Review of DOD's approach to deriving an occupational exposure level for trichloroethylene / | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CORP Author | National Academies of Sciences, Engineering, and Medicine (U.S.). Committee to Review DOD's Approach to Deriving an Occupational Exposure Limit for TCE, | |||||||||||
Publisher | The National Academies Press, | |||||||||||
Year Published | 2019 | |||||||||||
OCLC Number | 1151354964 | |||||||||||
ISBN | 9780309499248; 0309499240 | |||||||||||
Subjects | Trichloroethylene--Threshold limit values ; Solvents--Threshold limit values ; Biological exposure indices (Industrial toxicology) | |||||||||||
Holdings |
|
|||||||||||
Collation | x, 65 pages : figures, tables ; 23 cm | |||||||||||
Notes | Includes bibliographical references. |
|||||||||||
Contents Notes | "Trichloroethylene (TCE) is a solvent that is used as a degreasing agent, a chemical intermediate in refrigerant manufacture, and a component of spot removers and adhesives. It is produced in mass quantities but creates dangerous vapors and is an environmental contaminant at many industrial and government facilities, including facilities run by the U.S. Department of Defense (DoD). It is important to determine the safe occupational exposure level (OEL) for the solvent in order to protect the health of workers who are exposed to its vapors. However, there are concerns that the current occupational standards insufficiently protect workers from these health threats. Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene makes recommendations to improve the DoD's approach to developing an OEL for TCE, strengthen transparency of the process, and improve confidence in the final OEL value. This report reviews the DoD's approach using a literature review, evidence synthesis based on weight of evidence [WOE], point-of-departure derivation, physiologically based pharmacokinetic modeling, extrapolation tools, and explores other elements of the process of deriving an OEL for TCE. It examines scientific approaches to developing exposure values and cancer risk levels, defining the scope of the problem, and improving hazard identification"--Publisher's description Introduction -- Approaches to developing exposure values -- Scoping and problem formulation -- Hazard identification -- Quantitative dose-response assessment and derivation of occupational exposure levels -- Conclusions -- Appendixes |