Record Display for the EPA National Library Catalog

RECORD NUMBER: 112 OF 217

OLS Field Name OLS Field Data
Main Title Subchronic Toxicity of Tetrachloroethylene (Perchloroethylene) Administered in the Drinking Water of Rats.
Author Hayes, J. R. ; Condie, L. W. ; Borzelleca, J. F. ;
CORP Author Medical Coll. of Virginia, Richmond. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA-R-808861; EPA/600/J-86/118;
Stock Number PB86-229812
Additional Subjects Toxicity ; Potable water ; Hazardous materials ; Exposure ; Chlorine organic compounds ; Water pollution ; Rats ; Reprints ; Tetrachloroethylene ; Ethylene/perchloro ; Ingestion ; Lethal doses
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB86-229812 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 9p
Abstract
The study provides data on the effects of tetrachloroethylene in drinking solutions. The acute oral LD(50) was determined in male and female Charles River rats and found to be 3835 mg/kg for males and 3005 mg/kg for females. Male and female rats received theoretical daily doses of 14,400 and 1400 mg tetrachloroethylene/kg bw/day for 90 consecutive days. There were no compound related deaths. There were no consistent dose related effects on any of the hematological or urinalysis parameters. There were no gross pathological effects observed. Liver and kidney ratios were elevated at the higher doses. There was no apparent evidence of accumulation. These data suggest that exposure of humans to reported levels of tetrachloroethylene in drinking water does not constitute a serious health hazard.