Abstract |
Timed pregnant CD-1 mice were exposed to captan or folpet by the intragastric, subcutaneous or inhalation route. A dose of 100 mg/kg/day of captan or folpet was administered subcutaneously or intragastrically from day 6-15 of gestation. The dose levels for the inhalation route were averaged from daily exposure levels determined by monitoring the chambers. The inhalation route provided daily average concentrations approximating 491 mg/hr/cu. m. for captan and 624 mg/hr/cu. m. for folpet, four hr/day from the 6th to the 13th day of gestation. The particle size was less than 5 micrometers. There was approximately 10% material mortality with both captan and folpet by the inhalation route, while no mortality was seen by the other two routes. The only fetal toxicity noted was a reduction in fetal body weight in the group administered captan subcutaneously. Neither captan or folpet were teratogenic in CD-1 mice exposed by the subcutaneous, oral or inhalation routes. |