Record Display for the EPA National Library Catalog

RECORD NUMBER: 23 OF 42

OLS Field Name OLS Field Data
Main Title Interaction of Inorganic Mercury Salts with Model and Red Cell Membranes: Importance of Lipid Binding Sites.
Author Delnomdedieu, M. ; Allis., J. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;French Foreign Ministry Lavoisier Program, Paris (France),
Publisher 1993
Year Published 1993
Report Number EPA/600/J-94/206;
Stock Number PB94-163854
Additional Subjects Receptor sites(Physiology) ; Lipids ; Mercury nitrates ; Mercury chlorides ; Membranes ; Erythrocytes ; Rats ; Anisotropy ; Temperature effects ; Physicochemical properties ; Heavy metals ; Fluorescence ; Concentration (Composition) ; pH ; Models ; Toxicity ; Mercury inorganic compounds ; Reprint ; Model membranes ; PS(Phosphatidylserine)
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB94-163854 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/01/1994
Collation 19p
Abstract
The effect of two mercury salts, HgCl2 and Hg(NO3)2, on the thermotropic properties of phosphatidylserine (PS) model membranes and sonicated rat red cell membranes was investigated by fluorescence polarization. Both Hg(II) salts abolished the phase transition and decreased the membrane fluidity by interacting with PS. These results indicate that besides protein thiol groups, Hg(II)-lipid binding sites play an important role in the interaction of Hg(II) with red cell membranes that is qualitatively different from Hg(II) binding to protein thiol groups. (Copyright (c) 1993 Elsevier Scientific Publishers Ireland Ltd.)