Record Display for the EPA National Library Catalog

RECORD NUMBER: 43 OF 329

OLS Field Name OLS Field Data
Main Title Catalytically and Noncatalytically Treated Automobile Exhaust: Biological Effects in Rats.
Author Cooper, G. P. ; Lewkowski, James P. ; Hastings, Lloyd ; Malanchuk, M. ;
CORP Author Cincinnati Univ., OH. Dept. of Environmental Health.;Health Effects Research Lab., Cincinnati, OH.
Year Published 1981
Report Number EPA-68-03-0492; EPA/600/J-77-181;
Stock Number PB81-238156
Additional Subjects Exhaust emissions ; Toxicology ; Rats ; Laboratory animals ; Exposure ; Sulfuric acid ; Carbon monoxide ; Growth ; Physiological effects ; Blood chemical analysis ; Reprints ; Biological effects ; Automobile exhaust ; Toxic substances ; Motor activity
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB81-238156 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 14p
Abstract
Chronic exposure to catalytically treated or noncatalytically treated automobile exhaust significantly depressed the spontaneous locomotor activity (SLA) of rats. Exposure to H2SO4 alone or CO at comparable levels did not alter the SLA. Exposure to noncatalytically treated exhaust resulted in significant reductions in growth rate and food and water intake. However, these effects were not evident in the exposure to catalytically treated exhaust or in the control H2SO4 and CO exposures. Blood acid-base analyses indicated that exposure to either catalytically treated exhaust or H2SO4 elicits a metabolic alkalosis, while exposure to CO alone results in a metabolic acidosis. All acid-base parameters were within the normal range several weeks after the termination of exposure.