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RECORD NUMBER: 8 OF 9

OLS Field Name OLS Field Data
Main Title Thermoregulatory Responses of the Rabbit to Central Neural Injections of Sulfolane.
Author Mohler, R. S. ; Gordon, C. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/326;
Stock Number PB90-216037
Additional Subjects Toxicity ; Central nervous system ; Thermoregulation ; Hypothermia ; Rabbits ; Solvents ; Graphs(Charts) ; Hazardous materials ; Body temperature ; Exposure ; Metabolism ; Reprints ; Sulfolane ; Toxic substances ; Dose-response relationships ; Polycyclic sulfur heterocycles ; Occupational safety and health
Holdings
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Status
NTIS  PB90-216037 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/27/1990
Collation 13p
Abstract
Systemic exposure of the rabbit to sulfolane results in hypothermia. The study was designed to determine the thermoregulatory effects of sulfolane on the central nervous system (CNS) of the rabbit. Male rabbits were stereotaxically implanted with an injection cannula over the preoptic/anterior hypothalamic area (POAH) or into the lateral cerebral ventricle. POAH temperature T(POAH), ear temperature, T(e) and metabolic rate (MR) were recorded at an ambient temperature T(a) of 15 C. No changes were observed in any of the thermoregulatory indices following injections of saline or sulfolane in dosages of 100, 300, and 1000 micrograms directly into the POAH. Intracerebroventricular (ICV) injection of saline also had no effect on thermoregulation. However, ICV sulfolane in dosages of 300, 1000, and 3000 micrograms caused T(POAH) to rise 0.23, 0.47, and 0.56 C, respectively. The hyperthermia was significant at a dosage of 3000 micrograms. There was no change in T(e) or MR at the three dose levels. Microinjection of 10,000 micrograms sulfolane ICV caused a slight decrease in T(POAH) for 30 min which was accompanied by an increase in T(e). Following the slight decrease, T(POAH) increased to +0.54 C at 120 min after injection as T(e) returned to baseline values. The data suggest that the previously observed thermoregulatory effects of sulfolane following systemic exposure cannot be attributed to a direct action of the parent compound on the CNS. (Copyright (c) 1989 by Intox Press, Inc.)