Record Display for the EPA National Library Catalog

RECORD NUMBER: 14 OF 34

OLS Field Name OLS Field Data
Main Title Effect of industrial particulate samples on alveolar macrophages /
Author Aranyi, Catherine.
CORP Author IIT Research Inst., Chicago, IL. Life Sciences Research Div.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Health Effect Research Laboratory,
Year Published 1981
Report Number EPA/600/1-81/003; EPA-R-805141
Stock Number PB81-150963
OCLC Number 48844703
Subjects Particles. ; Air--Pollution. ; Macrophages.
Additional Subjects Macrophages ; Toxicology ; Steel plants ; In vitro analysis ; Rabbits ; In vivo analysis ; Inhalation ; Exposure ; Air pollution ; Bioassay ; Toxic substances ; Particulates ; Cytotoxicity ; Air pollution effects(Animals)
Holdings
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Status
NTIS  PB81-150963 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 49 pages ; 28 cm
Abstract
Toxic ranking of the <3 micrometer size fraction of particulate samples by in vitro rabbit alveolar macrophage assay showed generally low to intermediate cytotoxicity for samples obtained from a steel foundry, an electric arc furnace steel plant and from four coal-fired power plants. Particulates obtained from an aluminum and from a copper smelter were highly toxic to alveolar macrophages as monitored by viability, total cellular protein and ATP levels. The two smelter samples also contained soluble components that significantly contributed to their cytotoxicity. None of the particulate samples tested were true emission or effluent samples, but were collected from in-plant control devices. Inhalation of copper smelter particle aerosols produced significant changes in more of the parameters than inhalation of the coal fly ash. Thus, the overall objective of these studies was realized by demonstrating the validity of prediction of inhalation hazard on the basis of the in vitro screening assay.
Notes
Caption title. "January 1981." "EPA-600/1-83-003." Microfiche.