||Combining Pharmacokinetic and Cancer Bioassay Data.
Whittemore., A. S. ;
||Stanford Univ., CA. Dept. of Family, Community and Preventive Medicine.;National Institutes of Health, Bethesda, MD.;Electric Power Research Inst., Palo Alto, CA.;Alfred P. Sloan Foundation, New York.;Health Effects Research Lab., Research Triangle Park, NC.
||NIH-PHS-00070 ;NIH-PHS-CA-23214; EPA/600/D-90/047;
Laboratory animals ;
Risk assessment ;
Carcinogenicity tests ;
Predictive value of tests ;
Dose-response relationships ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Despite formidable sources of uncertainty, risk assessments are needed to avoid the extremes of either banning or allowing all exposures to potentially harmful chemicals. The paper addresses methods for reducing uncertainty in relationships between human exposures and disease, particularly cancer. Attention will focus on possible improvements in the use of animal experiments to predict human cancer risks.