The Missouri-Souris portion of the land and water resources development program for the Missouri River Basin includes that reach of the Missouri River from below the mouth of Milk River in Montana to the mouth of Spring Creek, South Dakota, the Devils Lake Area, the James River Basin, and the United States portions of the Souris and Red River Basins. The plan calls for diversion of Missouri River water at strategic points for multipurpose use and to supplement available water in the Souris, Red, and James River Basins. This report covers the Missouri-Souris-Red area. The James River Basin will be presented in another report. Among the many contemplated water uses of the resource conservation plan are those for municipal, industrial, public health, sanitation and related purposes. In order to determine these needs, information is required on present water quantity and quality; and types, sources, and extent of pollution in streams of the region. A general section of the report deals with over-all water supply and water pollution problems pertinent to the area and includes survey methods, review of State Water Pollution Control Law, conclusions and recommendations. The major sub-basins are discussed in detail in separate sections of the report. Pertinent detail information, laboratory and flow data, and other presentations are included as appendixes.