Record Display for the EPA National Library Catalog

RECORD NUMBER: 4 OF 36

OLS Field Name OLS Field Data
Main Title Compatibility of Organic Solvents with the Microscreen Prophage-Induction Assay: Solvent - Mutagen Interactions.
Author DeMarini, D. M. ; Lawrence, B. K. ; Brooks, H. G. ; Houk., V. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Durham, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/164;
Stock Number PB91-231324
Additional Subjects Mutagens ; Organic solvents ; Toxicity ; Phage lambda ; Mutagenicity tests ; Escherichia coli ; Metabolic activation ; Hexanes ; Acetone ; Benzene ; Chloroform ; Ethyl alcohol ; Propyl alcohol ; Carbinols ; Toluene ; Xylenes ; Chloromethanes ; Dimethyl sulfoxide ; Reprints ; Aminoanthracenes ; Nitrofluorenes
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-231324 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/26/1991
Collation 9p
Abstract
The following solvents did not induce prophage lambda in the Escherichia coli WP2 lambda Microscreen assay: acetone, benzene, chloroform, ethanol, n-hexane, isopropanol, methanol, toluene, and a mixture of the three isomers of xylene. Dimethyl sulfoxide was genotoxic in the presence and absence of S9, and methylene chloride was weakly genotoxic in the presence of S9. The genotoxic potencies of 2-aminoanthracene and 2-nitrofluorene were reduced when dissolved in DMSO or methanol compared to their potencies when dissolved in acetone. (Copyright (c) 1991 Elsevier Science Publishers B.V.)