||Thermoregulatory Responses of the Rabbit to Subcutaneous Injection to Sulfolane (Journal Version).
Mohler, F. S. ;
Gordon, C. J. ;
||Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Hazardous materials ;
Body temperature ;
Central nervous system ;
Toxic substances ;
Dose-response relationships ;
Polycyclic sulfur heterocycles ;
Occupational safety and health
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The study was designed to determine the thermoregulatory effects of sulfolane on the central nervous system (CNS) of the rabbit. POAH temperature (T sub POAH), ear temperature (T sub e), and metabolic rate (MR) were recorded at an ambient temperature (T sub a) of 15 C. No changes were observed in any of the thermoregulatory indices following injections of saline or sulfolane and intracerebroventricular (ICV) injection of saline. ICV sulfolane caused T sub POAH to rise 0.23 to 0.56 C. This hyperthermia was significant at a dosage of 3000 micrograms. Microinjection of 10,000 micrograms sulfolane ICV caused a slight decrease in T sub POAH for 30 min followed by an increase to +0.54 C at 120 min after injection. The hypothermia was accompanied by an increase in T sub e which returned to baseline values as the sulfolane-induced hyperthermia began. MR was not affected by sulfolane exposure. The data suggest that the previously observed thermoregulatory effects of sulfolane following systemic exposure cannot be attributed to a direct action of the compound on the CNS.