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RECORD NUMBER: 13 OF 270

OLS Field Name OLS Field Data
Main Title Analysis of Alkyl Phosphates by Extractive Alkylation.
Author Bradway, Diane E. ; Moseman, Robert ; May, Randy ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Analytical Chemistry Branch.
Year Published 1981
Report Number EPA-600/J-81-033;
Stock Number PB82-124231
Additional Subjects Pesticides ; Chemical analysis ; Urine ; Organic phosphates ; Solvent extraction ; Isomers ; Concentration(Composition) ; Reprints ; Phosphorothioic acid/(dimethyl-ester) ; Phosphorothioic acid/(diethyl-ester)
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB82-124231 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 6p
Abstract
The development of suitable methods for analysis of the alkyl phosphate metabolites of organophosphorus pesticides in urine has been a rather difficult and persistent problem. Currently available methodology suffers from several shortcomings. The extraction of the compounds from urine is often incomplete and inconsistent. The reagent used in derivatization, diazopentane, and its precursor, a substituted nitrosoguanidine, present unacceptable hazards to the analyst, principally because of the demonstrated mutagenicity and/or carcinogenicity of the reagents. In addition, when dimethylphosphorothioate and diethylphosphorothioate are derivatized with diazoalkanes, they to give two isomeric products: a phosphorothionate and a phosphorothiolate. It is therefore, uncertain that the ratio of the isomers is constant. The limit of detection is higher than would be the case if only one product were formed.