Record Display for the EPA National Library Catalog

RECORD NUMBER: 1945 OF 2071

OLS Field Name OLS Field Data
Main Title Use of Simulation Modeling in Exposure and Risk Assessment.
Author Blancato, J. N. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Year Published 1988
Report Number EPA/600/D-88/070;
Stock Number PB88-195185
Additional Subjects Exposure ; Risk ; Assessments ; Simulation ; Toxicity ; Toxicology ; Physiological effects ; Public health ; Dosage ; Models ; Risk assessment
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB88-195185 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1988
Collation 21p
Abstract
Physiologically based pharmacokinetic models provide a useful means of evaluating the impact of different exposure scenarios upon certain components of the risk assessment. In the paper, a physiologically based pharmacokinetic model used for risk assessment purposes in 1987, was used to determine pulmonary absorption fractions the amount of metabolite formed at various exposure concentrations. The effect of various model parameters such as the metabolic rate constants and the blood to air partition ratios were examined. The paper illustrates the usefulness of such models to test the impact of various assumptions and exposure scenarios upon risk. They are not a replacement for soundly determined data but can be an important adjunct in the interpretation and use of such data.