Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 4

OLS Field Name OLS Field Data
Main Title Supplemental Information: Trimethoxysilane: Acute Percutaneous Toxicity and Skin Irritancy Studies in the Rabbit (Final Report) with Attachments and Cover Letter dated 01/10/92.
CORP Author Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center. ;Union Carbide Corp., Danbury, CT.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 15 Jan 1992
Year Published 1992
Report Number 8HEQ-0192-0347;
Stock Number OTS-0204852-5
Additional Subjects Toxicity ; Skin(Anatomy) ; Rabbits ; Irritation ; Chemical analysis ; Clinical pathology ; Lesions ; Silanes ; Laboratory tests ; Kidney ; Urinary bladder ; Histology ; Evaluation ; Trimethoxysilane ; Union Carbide Chemicals and Plasics Company
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NTIS  OTS-0204852-5 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 07/09/2008
Collation 31p
Abstract
In previous rabbit cutaneous testing at BRRC, trimethoxysilane (CAS No. 2487-90-3) was not evaluated for nephrotoxic potential, a feature shown to be common to a number of other related silanes. Therefore, trimethoxysilane was reevaluated for percutaneous toxicity in the female rabbit with the addition of kidney and urinary bladder histology. In previous tests, trimethoxysilane was found to be a DOT 'corrosive' to rabbit skin in the 4-hour occluded test. In order to further determine the classification of this material on the basis of skin corrosivity, both 1-hour and 3-minute tests were done. All tests were conducted using standard BRRC methods.