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RECORD NUMBER: 32 OF 189

OLS Field Name OLS Field Data
Main Title Critical Evaluation of Methods for Detection and Assessment of Estrogenic Compounds in Mammals: Strengths and Limitations for Application to Risk Assessment.
Author Kupfer, D. L. ;
CORP Author Worcester Foundation for Experimental Biology, Shrewsbury, MA.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/294 ; OHEA-R-255
Stock Number PB89-202295
Additional Subjects Reproduction(Biology) ; Toxicology ; Sex hormones ; Estrogens ; Reprints ; Xenobiotics ; Risk assessment ; Proestrogens ; Therapeutic agents
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB89-202295 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/18/1989
Collation 10p
Abstract
Methods for assessing proestrogenic and estrogenic activity of xenobiotics (environmental pollutants and therapeutic agents) are critically evaluated. The uterotropic assay in vivo and the binding affinity to the uterine estrogen receptor in vitro are still the preferred methods by most investigators. Because metabolism could markedly alter the activity of estrogens and proestrogens, in vitro methods that do not consider such possibilities have only limited utility. An in vitro method, which attempts to satisfy that requirement by combining metabolic capability with binding to the estrogen receptor, has become available. However, this method still needs considerable refinement and the assessment of its potential and limitations. In addition, there is a need for a facile method for determining whether a compound is a frank estrogen or a partial agonist/antiestrogen. These methods are considered in respect to their application for risk assessment. (Copyright (c) 1988 Pergamon Press plc.)