Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 128

OLS Field Name OLS Field Data
Main Title Antimutagenicity Profiles for Some Model Compounds.
Author Waters, M. D. ; Brady, A. L. ; Stack, H. F. ; Brockman, H. E. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Illinois State Univ., Normal. Dept. of Biological Sciences.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/019;
Stock Number PB90-217407
Additional Subjects Toxicology ; Mutagens ; Tables(Data) ; Salmonella typhimurium ; Reprints ; Mutagenicity tests ; Metabolic activation
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-217407 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/27/1990
Collation 31p
Abstract
The concept of activity profile listings and plots, already applied successfully to the display of mutagenicity data, has been modified for the application to antimutagenicity data. The activity profiles are bar graphs that have been organized in two general ways: for antimutagens that have been tested in combination with a given mutagen and for mutagens that have been tested in combination with a given antimutagen. Doses from both the mutagen and the antimutagen are displayed and plotted against the resultant enhancement or inhibition of mutagenic activity. The short-term tests that have been used extensively to identify mutagens and potential carcinogens are increasingly being used to identify antimutagens and potential anticarcinogens. Three model mutagens, N-methyl-N'-nitro-N-nitrosoguanidine, aflatoxin B1 and benzo(a)pyrene, and four model antimutagens, butylated hydroxyanisole, butylated hydroxytoluene, glutathione and disulfiram, were selected from the data surveyed in the published literature. It is not clear at the present time whether the inhibition of carcinogen-induced mutation is a good indicator of anticarcinogenic properties, and further research in that area is needed. (Copyright (c) 1990 Elsevier Scientific Publishers B. V.)