Record Display for the EPA National Library Catalog

RECORD NUMBER: 265 OF 2643

OLS Field Name OLS Field Data
Main Title Carcinogenicity of Benzo(a)pyrene in Rainbow Trout Resulting from Embryo Microinjection.
Author Black, J. J. ; Maccubbin, A. E. ; Johnston, C. J. ;
CORP Author Roswell Park Memorial Inst., Buffalo, NY. Dept. of Experimental Biology.;Environmental Research Lab.-Duluth, MN.
Publisher c1988
Year Published 1988
Report Number EPA-R-811689; EPA/600/J-88/458;
Stock Number PB90-147653
Additional Subjects Toxicity ; Embryos ; Trout ; Exposure ; Dosimetry ; Liver neoplasms ; Metabolism ; Mortality ; Tables(Data) ; Reprints ; Salmo gairdneri ; Carcinogenicity tests ; Benzo(a)pyrene ; Water pollution effects(Animals) ; Dose-response relationships ; Microinjections ; High pressure liquid chromatography
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB90-147653 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/15/1990
Collation 13p
Abstract
Rainbow trout (Salmo gairdneri) embryos were exposed in ovo to benzo(a)pyrene (BaP) by a single transchorionic injection. Injected BaP was retained in the yolk sac of larval trout and was only slowly metabolized until swim-up. One year post-exposure, BaP-treated fish had an elevated incidence of liver neoplasms which ranged from small basophilic microfoci of altered hepatocytes to large hepatocellular carcinomas. These results demonstrate carcinogenesis in rainbow trout from single dose exposure to BaP, a widely distributed environmental pollutant that has been implicated as the cause of liver neoplasia in wild fish and some human cancers. (Copyright (c) 1988 Elsevier Science Publishers B.V.)