Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Tolerance to Methacholine Inhalation Challenge in Nonasthmatic Subjects.
Author Beckett, W. S. ; McDonnell, W. F. ; Wong, N. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Yale Univ., New Haven, CT. School of Medicine.
Year Published 1988
Report Number EPA/600/J-88/103;
Stock Number PB88-251715
Additional Subjects Methacholines ; Asthma ; Diagnostic agents ; Respiration ; Diagnosis ; Reprints ; Drug tolerance ; Bronchial provocation tests ; Respiratory function tests
Library Call Number Additional Info Location Last
NTIS  PB88-251715 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/29/1988
Collation 5p
Airway responses to inhalation challenge with methacholine in healthy nonasthmatic subjects were examined to determine whether attenuation of response occurred upon repeated challenge. In one experiment, progressively increasing tolerance to multiple-dose challenges was seen with 4 challenges at 4 h intervals. In another study, a smaller degree of tolerance was also seen when a single-dose challenge was conducted 3 times at 24 h intervals. In these studies, the doses of methacholine used to obtain responses in nonasthmatic subjects were higher than are required under conditions of clinical methacholine challenge as a diagnostic test for asthma. Consequently, these findings may be relevant only to investigations or epidemiologic studies in which serial methachloline challenges are performed at intervals of 24 h or less in nonasthmatic subjects requiring higher cumulative doses of methacholine than do asthmatics.