| Main Title |
Effect of duck hepatitis virus on pesticide toxicity / |
| Author |
Ragland, William Lauman, ;
Ragland., W. L.
|
| CORP Author |
Georgia Univ., Athens. Poultry Disease Research Center.;Health Effects Research Lab., Research Triangle Park, N.C. |
| Publisher |
U.S. Environmental Protection Agency, Health Effects Research Laboratory, |
| Year Published |
1976 |
| Report Number |
EPA-600/1-76-003; EPA-R801800 |
| Stock Number |
PB-249 351 |
| OCLC Number |
42786718 |
| Subjects |
Virology--Research ;
DDT (Insecticide)--Research ;
Newcastle disease vaccine
|
| Additional Subjects |
Enzymes ;
Liver ;
Pesticides ;
Hepatitis viruses ;
Metabolism ;
Induction ;
Reticuloendothelial system ;
DDT ;
Tissues(Biology) ;
Ducks ;
Newcastle disease virus ;
Drugs ;
Bioaccumulation ;
Pesticide residues
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-76-003 |
|
Headquarters Library/Washington,DC |
01/17/2014 |
| EKBD |
EPA-600/1-76-003 |
|
Research Triangle Park Library/RTP, NC |
02/11/2000 |
| ELBD ARCHIVE |
EPA 600-1-76-003 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD |
EPA 600-1-76-003 |
|
AWBERC Library/Cincinnati,OH |
11/15/2016 |
| NTIS |
PB-249 351 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
viii, 63 pages ; 28 cm. |
| Abstract |
The report presents the results of an investigation into the effect of viral replication on hepatic endoplasmic reticulum on the activities of the microsomal drug-metabolizing enzymes of liver. Two viruses which replicate on hepatic endoplasmic reticulum without producing hepatic disease were used. They were Newcastle disease vaccinal virus in chickens and duck hepatitis virus in adult ducks. The microsomal enzymes assayed were ethylmorphine N-demethylase, aryl hydrocarbon hydroxylase and anyline hydroxylase. The soluble enzyme, nitroreductase, also was assayed in chickens. Pesticide residue analysis was used to evaluate indirectly the microsomal enzymatic conversion of DDT to DDD and the soluble enzymatic conversion of DDT to DDE in ducks. Viral replication did not increase the activities of the microsomal enzymes and may have decreased the activities slightly. Although the microsomal enzymes were induced to greater levels by viral replication, pesticide residue analysis failed to demonstrate increased clearance of residues from body tissues. |
| Notes |
"EPA-600/1-76-003." EPA grant no. R801800; EPA project officer: Ronald L. Baron. Includes bibliographical references (pages 59-61). |
